Abstract
IT has been suggested that a defect of acetylcholine synthesis in motor nerve endings would account best for the peculiar features of neuromuscular block seen in myasthenic patients1. This hypothesis can be tested by investigating the effect on the skeletal muscle of the cat of a recently developed drug2, hemicholinium base HC3, which strongly inhibits the synthesis of acetylcholine by nervous tissue3.
This is a preview of subscription content, access via your institution
Access options
Similar content being viewed by others
References
Desmedt, J. E., Rev. Neurol. (Paris), 96, 505 (1957); J. Physiol., 140, 3P (1958).
Schueler, F. W., J. Pharmacol., 115, 127 (1955).
MacIntosh, F. C., Birks, R. I., and Sastry, P. B., Nature, 178, 1181 (1956). Gardiner, J. E., J. Physiol., 138, 13P (1957). MacIntosh, F. C., Birks, R. I., and Sastry, P. B., Neurology, 8, 90 (1958).
Rosenblueth, A., and Morison, R. S., Amer. J. Physiol., 119, 236 (1937).
Harvey, A. M., and Masland, R. L., Bull. J. Hopkins Hosp., 69, 1 (1941).
Desmedt, J. E., Nature, 179, 156 (1957).
Churchill-Davidson, H. C., and Richardson, A. T., J. Physiol., 122, 252 (1953).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
DESMEDT, J. Myasthenic-like Features of Neuromuscular Transmission after Administration of an Inhibitor of Acetylcholine Synthesis. Nature 182, 1673–1674 (1958). https://doi.org/10.1038/1821673a0
Issue date:
DOI: https://doi.org/10.1038/1821673a0
