Abstract
VARIOUS lines of evidence, for example, involvement of sulphydryl groups and adenosine triphosphatase, suggest that the rate-limiting process for muscular contraction may be proton transfer. In this event, one would expect the rate of either isometric or isotonic contraction to be slowed up in the presence of heavy water (D2O). According to a recent analysis1, which of the two most affected will depend on whether activation or production of tension is involved.
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References
Goodall, M. C., Yale J. Biol. Med., 30, 224 (1957).
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GOODALL, M. Kinetics of Muscular Contraction in Heavy Water. Nature 182, 677 (1958). https://doi.org/10.1038/182677a0
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DOI: https://doi.org/10.1038/182677a0
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