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An Attempt to Produce Malignant Change with Deoxyribonucleic Acid from Rat Sarcoma and Hepatoma

Nature volume 184, page 824 (1959)Cite this article

Abstract

BENOIT, Leroy, Vendrely and Vendrely1,2,3,4 have described changes in the pigmentation of the Pekin duckling after injection of deoxyribonucleic acid from the Khaki-Campbell drake, which they interpreted as a somatic mutation. Perry and Walker5 and Bearn and Kirby6 have repeated similar work in the rat and failed to produce any change. Hewer and Meek7 injected young mice with deoxyribonucleic acid from herring sperm, and within 23 days produced death from malignant disease of the intestine. Leuchtenberger, Leuchtenberger and Uyeki8 produced cytological changes in the livers of mice by intraperitoneal injection of deoxyribonucleic acid prepared from breast cancers of C 3 H mice. This work has now been repeated in the rat using deoxyribonucleic acid prepared from rat sarcoma and rat hepatoma.

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References

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Authors and Affiliations

  1. Department of Anatomy, Middlesex Hospital Medical School, London, W.1

    J. G. BEARN

Authors
  1. J. G. BEARN
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BEARN, J. An Attempt to Produce Malignant Change with Deoxyribonucleic Acid from Rat Sarcoma and Hepatoma. Nature 184, 824 (1959). https://doi.org/10.1038/184824a0

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