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Isolation of a Phagocytosis-inhibiting Substance from Culture Filtrates of an Encapsulated Staphylococcus aureus

Nature volume 186, pages 102–103 (1960)Cite this article

Abstract

COAGULASE-negative strains of Staphylococcus albus added to suspensions of rabbit polymorphonuclear leucocytes in normal rabbit serum are rapidly phagocytosed and destroyed; in contrast, coagulase-positive strains of Staphylococcus aureus resist ingestion and survive extra-cellularly. The addition of anti-serum prepared against heat-killed S. aureus results in efficient phagocytosis and intracellular killing of the homologous organism1. The present communication describes the isolation and properties of a substance obtained from culture filtrates of an encapsulated S. aureus which interferes with its phagocytosis.

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References

  1. Cohn, Z. A., and Morse, S. I., J. Exp. Med., 110, 419 (1959).

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  2. Goebel, W. F., Barry, G. T., and Shedlovsky, T., J. Exp. Med., 103, 135 (1956).

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Authors and Affiliations

  1. Rockefeller Institute, New York, 21

    STEPHEN I. MORSE

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  1. STEPHEN I. MORSE
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MORSE, S. Isolation of a Phagocytosis-inhibiting Substance from Culture Filtrates of an Encapsulated Staphylococcus aureus . Nature 186, 102–103 (1960). https://doi.org/10.1038/186102a0

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