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Antigen-induced Damage to Isolated Sensitized Mast Cells

Nature volume 186, pages 245–246 (1960)Cite this article

Abstract

THERE is now quite convincing evidence that damage to mast cells always occurs when histamine is released during anaphylaxis. Thus damage to these cells is known to occur after active or passive sensitization either when antigen is injected in the intact animal or when a piece of sensitized tissue is incubated with the specific antigen1. However, all the evidence is derived from experiments made with tissues containing not only mast cells but also a mixed cell population, and therefore it is not possible to know whether damage to the mast cells is a direct consequence of the antigen–antibody reaction or whether antibodies are located on or in the mast cells.

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References

  1. Mota, I., thesis, University of S. Paulo (1953); Brit. J. Pharm., 12, 453 (1957); J. Physiol., 140, 6P (1957); Nature, 182, 1021 (1958); J. Physiol. (in the press). Mota, I., and Vugman, I., Nature, 177, 427 (1956).

    Google Scholar 

  2. Padawer, J., and Gordon, A. S., Proc. Soc. Exp. Biol Med. N.Y., 88, 29 (1955).

    Article  CAS  Google Scholar 

  3. Strangeways, T. S. P., and Canti, R. G., Quart. J. Micro. Sci., 71, 1 (1927).

    Google Scholar 

  4. Mota, I., Beraldo, W. T., and Junqueira, L. C. U., Proc. Soc. Exp. Biol. Med. N.Y., 83, 455 (1953).

    Article  CAS  Google Scholar 

  5. Humphrey, J. H., and MOta, I., Immunology, 2, 31 (1959).

    CAS  PubMed  PubMed Central  Google Scholar 

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Author notes

  1. W. DIAS DA SILVA: Fellow from the C.A.P.E.S.

Authors and Affiliations

  1. Laboratory of Cell Physiology and Department of Histology, Faculty of Medicine, University of São Paulo, Brazil

    I. MOTA & W. DIAS DA SILVA

Authors
  1. I. MOTA
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  2. W. DIAS DA SILVA
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MOTA, I., DA SILVA, W. Antigen-induced Damage to Isolated Sensitized Mast Cells. Nature 186, 245–246 (1960). https://doi.org/10.1038/186245a0

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