Abstract
OXYGEN-15 has been prepared by deuteron bombardment of nitrogen molecules in the Medical Research Council cyclotron at Hammersmith Hospital. Gases labelled with this isotope, which has a half-life of only 2 min., can be inhaled into the lungs and detected by external scintillation counters. The initial counting-rate in a given region of the lung is proportional to the regional ventilation1, and the rate of removal from the region during breath-holding is a measure of the regional blood-flow2.
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References
Dyson, N. A., Hugh-Jones, P., Newbery, G. R., Sinclair, J. D., and West, J. B., Brit. Med. J., i, 231 (1960).
West, J. B., and Dollery, C. T., J. App. Physiol., 15, 405 (1960).
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DOLLERY, C., WEST, J. Metabolism of Oxygen-15. Nature 187, 1121 (1960). https://doi.org/10.1038/1871121a0
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DOI: https://doi.org/10.1038/1871121a0
