Abstract
PREVIOUS results published from this laboratory indicate that the increased mechanical efficiency (ratio of work output to energy input) apparent after the administration of non-toxic doses of cardiac glycosides to isolated spontaneously beating hearts is invariably associated with raised levels of oxidative metabolism1,2. Hajdu and Leonard3 recently directed attention to the possibility that such an increased rate of oxygen consumption could be due to the increased mechanical work output associated with the positive inotropic response rather than to the fundamental metabolic action of the glycosides themselves.
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References
Nayler, W. G., Aust. J. Exp. Biol. and Med. Sci., 34, 377 (1956).
Nayler, W. G., Aust. J. Exp. Biol. and Med. Sci., 35, 241 (1957).
Hajdu, S., and Leonard, E., Pharm. Rev., 11, 173 (1959).
Nayler, W. G., and McKelvie, D., Aust. J. Exp. Biol. and Med. Sci., 34, 377 (1956).
Wollenberger, A., Pharm. Rev., 1, 311 (1949).
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NAYLER, W. Effect of Strophanthin G on Oxidative Metabolism in Cardiac Muscle. Nature 188, 70–71 (1960). https://doi.org/10.1038/188070b0
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DOI: https://doi.org/10.1038/188070b0
