Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Letter
  • Published:

Glutamic Acid Metabolism in Brain and Liver during Infusion with Ammonia labelled with Nitrogen-15

Nature volume 189, page 326 (1961)Cite this article

Abstract

RECENT results of in vivo experiments using glutamic acid labelled with carbon-14 were consistent with the hypothesis that the amidation of the administered amino-acid to glutamine represents a metabolic event occurring in a tissue or cellular compartment1,2. Since glutamic acid and glutamine syntheses in the central nervous system are the two known processes by which ammonia enters organic linkage, it appeared of great interest to approach the question of setting into compartments the metabolism of glutamic acid and its derivatives with the aid of ammonia labelled with nitrogen-15.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on SpringerLink
  • Instant access to the full article PDF.

USD 39.95

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

References

  1. Lajtha, A., Berl, S., and Waelsch, H., J. Neurochem., 3, 322 (1959).

    Article  CAS  Google Scholar 

  2. Berl, S., Lajtha, A., and Waelsch, H., J. Neurochem. (in the press).

  3. Berl, S., and Waelsch, H., J. Neurochem., 3, 161 (1958), and unpublished methods.

    Article  CAS  Google Scholar 

  4. Berl, S., Purpura, D. P., Girado, M., and Waelsch, H., J. Neurochem., 4, 311 (1959).

    Article  CAS  Google Scholar 

  5. Flock, E. V., Block, M. A., Grindlay, J. H., Mann, F. C., and Bollman, J. L., J. Biol. Chem., 200, 529 (1953).

    CAS  PubMed  Google Scholar 

  6. Elliott, W. H., Biochem. J., 49, 106 (1951).

    Article  CAS  Google Scholar 

  7. Lajtha, A., Mela, P., and Waelsch, H., J. Biol. Chem., 205, 553 (1953).

    CAS  PubMed  Google Scholar 

  8. Schneider, W. C., in “Adv. in Enzymol.”, edit. by Nord, F. F., 21, 1 (Interscience Publ., New York, 1959).

    Google Scholar 

  9. Waelsch, H., Proc. Fourth Internat. Cong. Biochemistry, Vienna, 3, 36 (Pergamon Press, London, 1959).

  10. Waelsch, H., in “Structure and Function of the Cerebral Cortex” Proc. Internat. Meeting Neurobiologists, Amsterdam (Elsevier Publ. Co., 1960).

    Google Scholar 

Download references

Author information

Author notes

  1. G. TAKAGAKI: Fellow of the Rockefeller Foundation.

Authors and Affiliations

  1. New York State Psychiatric Institute and College of Physicians and Surgeons, Columbia University, New York

    G. TAKAGAKI, S. BERL, D. D. CLARKE, D. P. PURPURA & H. WAELSCH

Authors
  1. G. TAKAGAKI
    View author publications

    Search author on:PubMed Google Scholar

  2. S. BERL
    View author publications

    Search author on:PubMed Google Scholar

  3. D. D. CLARKE
    View author publications

    Search author on:PubMed Google Scholar

  4. D. P. PURPURA
    View author publications

    Search author on:PubMed Google Scholar

  5. H. WAELSCH
    View author publications

    Search author on:PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

TAKAGAKI, G., BERL, S., CLARKE, D. et al. Glutamic Acid Metabolism in Brain and Liver during Infusion with Ammonia labelled with Nitrogen-15. Nature 189, 326 (1961). https://doi.org/10.1038/189326a0

Download citation

  • Issue date:

  • DOI: https://doi.org/10.1038/189326a0

This article is cited by

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing