Abstract
ABNORMALITIES of both number and morphology of the chromosomes of leukæmia cells in man have been reported1,2. All such work reported to date has been made on cells from marrow or from peripheral blood cultured in vitro. Such findings are open to the theoretical objection that any observed abnormality might have arisen during the culture process. In order to obviate this possibility, we decided to attempt to take advantage of the situation in leukæmia where the bone marrow is abnormally active, and later developed a method of making preparations without prior culture3.
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Baikie, A. G., Court-Brown, W. M., Jacobs, P. A., and Milne, J. S., Lancet, ii, 425 (1959).
Baikie, A. G., Court-Brown, W. M., Buckton, K. E., Harnden, D. G., Jacobs, P. A., and Tough, I. M., Nature, 188, 1165 (1960).
Kinlough, M. A., Robson, H. N., and Hayman, D. L., Nature, 189, 420 (1961).
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KINLOUGH, M., ROBSON, H. Chromosome Preparations obtained directly from Peripheral Blood. Nature 192, 684 (1961). https://doi.org/10.1038/192684a0
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DOI: https://doi.org/10.1038/192684a0
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