Abstract
SINCE Freund first showed that a demyelinating encephalitis could be produced by the subcutaneous injection of brain tissue with an adjuvant prepared from tubercle bacilli, this method has been used to induce other auto-antibodies. Freund and other workers have shown aspermatogenesis following the injection of homologous testicular extract with an adjuvant1, and similarly other auto-antibodies have been produced against lens tissue2 and peripheral nerves3.
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References
Freund, J., Lipton, M. M., and Thompson, G. E., J. Exp. Med., 101, 591 (1955).
Halbert, S. P., Locather-Khorazo, D., Swick, L., Witmer, R., Seegal, B., and Fitzgerald, P., J. Exp. Med., 105, 439 (1957).
Waksman, B. H., and Adams, R. D., J. Exp. Med., 102, 213 (1955).
Graham, J., and Graham, R., Surg. Gynæcol. and Obst. (August 1959).
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RHODES, E. An Attempt to obtain Auto-immunity to Tumours with Freund's Adjuvant and Tetanus Toxoid. Nature 193, 1091 (1962). https://doi.org/10.1038/1931091a0
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DOI: https://doi.org/10.1038/1931091a0
