Abstract
MICROBIOLOGICAL reductions of α-keto-groups have been reported by Neuberg et al.1. Lemieux and Giquere2 carried out reductions of β-keto-caproic and β-keto-caprylic acids. Microbiological reductions of γ- and δ-keto-acids to yield optically active lactones have so far not been described in the literature.
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References
Neuberg, C., and Gorr, G., Biochem. Z., 154, 495 (1925).
Lemieux, R. U., and Giquere, J., Canad J. Chem., 29, 678 (1951).
Unilever, N. V., Belgian Pat. 592,593.
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MUYS, G., VAN DER VEN, B. & DE JONGE, A. Synthesis of Optically Active γ- and δ-Lactones by Microbiological Reduction. Nature 194, 995–996 (1962). https://doi.org/10.1038/194995b0
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DOI: https://doi.org/10.1038/194995b0
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