Abstract
Two groups of enzymes hydrolyse penicillins (I). The earlier of the two to be reported was penicillinase1, which opens the β-lactam ring to form the corresponding penicilloic acid (II). 
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BATCHELOR, F., WOOD, J. Formation of 6-Aminopenicillanic Acid by Alkaline Hydrolysis of Penicillins. Nature 195, 1000 (1962). https://doi.org/10.1038/1951000a0
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DOI: https://doi.org/10.1038/1951000a0
