Failure of Amino-nucleoside to produce Abnormalities in the Fœtus of the Rat

Abstract

IN an experimental study of urinary tract malformations, an attempt is being made in our laboratory to influence with chemical agents the embryonic development of the kidney. One substance that has been used is the amino-nucleoside derivative of ‘Puromycin^(R)’, which is known to produce increased albuminuria and the nephrotic syndrome in rats. Hallman et al.¹ have used this substance in attempts to induce a congenital nephrotic syndrome in experimental animals, and they have described renal tubular dilatation in some offspring of rats treated during the last days of pregnancy.