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Excretion of 5-Hydroxy Indolyl-Acetic Acid after Surgery

Nature volume 195, page 182 (1962)Cite this article

Abstract

ALTHOUGH the healing of a wound is an essentially local event, it must inevitably also involve wider metabolic processes in the whole organism. One metabolic excretory product of dietary tryptophan is 5-hydroxy indolyl-acetic acid (5-HIAA) derived via the intermediate metabolites 5-hydroxytryptophan (5-HTP) and 5-hydroxytryptamine (5-HT). Special interest has been devoted to this pathway because of its significance in carcinoid tumours. Certain of the metabolic and clinical changes produced by 5-HT may, however, also be important in tissue regeneration and the healing of wounds. As a method of investigating this, it was decided to study the excretion of 5-HIAA following wounding.

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References

  1. Udenfriend, S., Titus, E., and Weissbach, H., J. Biol. Chem., 216, 499 (1955).

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Authors and Affiliations

  1. Division of Wound Healing Research, Department of Surgery, University of Birmingham,

    NEVILLE CRAWFORD & GEORGE T. WATTS

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  1. NEVILLE CRAWFORD
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  2. GEORGE T. WATTS
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CRAWFORD, N., WATTS, G. Excretion of 5-Hydroxy Indolyl-Acetic Acid after Surgery. Nature 195, 182 (1962). https://doi.org/10.1038/195182a0

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