Effect of Posterior Pituitary Polypeptides on the Flow of Urine after Injection in Lateral Ventricle of the Brain of a Cat

Abstract

PREVIOUS observations in this laboratory have indicated that the injection of catecholamines and certain posterior pituitary polypeptides into the lateral ventricle of the cat is associated with characteristic and drug-specific pressor–depressor responses of the peripheral circulation¹. During the course of these earlier experiments, it was noted that the intraventricular introduction of posterior pituitary polypeptides was followed by a prompt increase of flow in urine. Other observers have reported that the peripheral administration of various posterior pituitary preparations may, on occasion, be attended by a rise of urine flow consequent to a solute diuresis^2,3. The present experiments were designed to define certain aspects of the ‘diuretic’ effect of these drugs during their central administration.