Abstract
RATS with large bilateral lesions of the lateral hypothalamus refuse to eat or drink and, unless force-fed and watered, die within two weeks of operation1–3. During an examination of these animals3 we noticed that the rate of loss of body-weight was greater and the duration of survival shorter than in intact rats deprived of food and water. Morgane4 has also remarked on this more rapid deterioration and has suggested that such lesions cause a specific ‘metabolic decay’.
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References
Anand, B. K., and Brobeck, J. R., Yale J. Biol. Med., 24, 123 (1951).
Anand, B. K., and Brobeck, J. R., Proc. Soc. Exp. Biol. and Med., 77, 323 (1951).
Montemurro, D. G., thesis, Univ. Western Ontario (1957).
Morgane, P. J., J. Comp. Neurol., 117, 1 (1961).
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STEVENSON, J., MONTEMURRO, D. Loss of Weight and Metabolic Rate of Rats with Lesions in the Medial and Lateral Hypothalamus. Nature 198, 92 (1963). https://doi.org/10.1038/198092a0
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DOI: https://doi.org/10.1038/198092a0
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