Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Letter
  • Published:

Induced Uphill and Downhill Transport: Relationship to the Ussing Criterion

Nature volume 198, pages 190–191 (1963)Cite this article

Abstract

DURING the entry of glucose into the human red cell there is an induced outward transport of radioglucose against its concentration gradient1. Similarly in the rabbit erythroeyte the entry of glucose induces an outward transport of xylose or galactose against a concentration gradient2. It is the purpose of this communication to show that this phenomenon is directly related to the ratio of the inward and outward fluxes across the membrane and to give a reversible thermodynamic derivation of the Ussing3 criterion.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on SpringerLink
  • Instant access to the full article PDF.

USD 39.95

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

References

  1. Rosenberg, T., and Wilbrandt, W., J. Gen. Physiol., 41, 289 (1957).

    Article  CAS  Google Scholar 

  2. Park, C. R., Post, R. L., Kalmaan, C. K., Wright, J. H., Johnson, L. H., and Morgan, H. E., Ciba Found. Coll. Endocrinol., 9, 240 (1956).

    Google Scholar 

  3. Ussing, H. H., Z. Elektrochem., 55, 470 (1951).

    CAS  Google Scholar 

  4. Hodgkin, A. L., and Keynes, R. D., J. Physiol., 128, 61 (1955).

    Article  CAS  Google Scholar 

  5. Britton, H. G., J. Physiol., 135, 61 P (1956).

    Google Scholar 

  6. LeFevre, P. G., and McGiniss, G. F., J. Gen. Physiol., 44, 87 (1960).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Physiology Department, St. Mary's Hospital Medical School, London, W.2

    H. G. BRITTON

Authors
  1. H. G. BRITTON
    View author publications

    Search author on:PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

BRITTON, H. Induced Uphill and Downhill Transport: Relationship to the Ussing Criterion. Nature 198, 190–191 (1963). https://doi.org/10.1038/198190a0

Download citation

  • Issue date:

  • DOI: https://doi.org/10.1038/198190a0

This article is cited by

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing