Abstract
THE present state of the research of the hæmostatic factor from peanuts (Arachis hypogaea, L.) (groundnuts) was recently reviewed in Nature by Astrup, Brakman and Sjolin1. These authors isolated from unroasted peanuts by extraction with calcium hydroxide and acetone precipitation an active protease inhibitor which affected the fibrinolytic system presumably as an anti-activator1,2. Ethanol extract of peanuts recommended for the treatment of hæmophilia by Boudreaux et al.3,4 revealed in Astrup's experiments only little or no antiprotease activity.
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References
Astrup, T., Brakman, P., and Sjolin, K. E., Nature, 194, 980 (1962).
Astrup, T., Brakman, P., Ollendorff, P., and Rasmussen, J., Thromb. Diath. Hæm., 5, 329 (1960).
Boudreaux, H. B., and Frampton, V. L., Nature, 185, 469 (1960).
Boudreaux, H. B., Boudreaux, R. M., Brandon, M., Frampton, V. L., and Lee, L. S., Arch. Biochem. Biophys., 89, 276 (1960).
Čepelák, V., Ztschr. Inn. Med., 16, 1100 (1961).
Čepelák, V., Horáková, Z., and Pádr, Z., Life Science (in the press).
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ČEPELÁK, V., HORÁKOVÁ, Z. & PÁDR, Z. Protease Inhibitor from Groundnut Skins. Nature 198, 295 (1963). https://doi.org/10.1038/198295a0
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DOI: https://doi.org/10.1038/198295a0
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