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Effect of 5-iodo-2′-deoxyuridine on Vaccinia Virus, in vitro

Nature volume 198, page 510 (1963)Cite this article

Abstract

SEVERAL reports have appeared recently regarding the effect of various halogenatedpyrimidines on herpes simplex virus1–3. 5-Iodo-2′-deoxyuridine (IUDR) and 5-fluoro-2′-deoxyuridine inhibit the herpes simplex virus growth, both in vitro and in vivo. These halogenated pyrimidines inhibit the biosynthesis of deoxyribonucleic acid by competing with thymidine in the synthesis of DNA-thymidine in mouse Ehrlich ascite cells.

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References

  1. Kaufman, H. E., Gustav Stern Symp. Virology, New York (Feb. 5, 1962).

  2. Perkins, E. S., Wood, R. M., Sears, M. L., Prusoff, W. H., and Welch, A. D., Nature, 194, 985 (1962).

    Article  ADS  CAS  Google Scholar 

  3. Lerman, S., Doyle, J., and Doyle, R. F., Nature, 194, 986 (1962).

    Article  ADS  CAS  Google Scholar 

  4. Loddo, B., Ferrari, W., Brotzu, G., and Spanedda, A., Boll. Ist. Sierot. Milan, 41, 111 (1962).

    CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Pharmacology and Departments of Hygiene and of Microbiology, University of Cagliari, Italy

    B. LODDO, S. MUNTONI & W. FERRARI

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  1. B. LODDO
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  2. S. MUNTONI
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  3. W. FERRARI
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LODDO, B., MUNTONI, S. & FERRARI, W. Effect of 5-iodo-2′-deoxyuridine on Vaccinia Virus, in vitro. Nature 198, 510 (1963). https://doi.org/10.1038/198510a0

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