Abstract
PREVIOUS autoradiographic and cytochemieal investigations1–4 have given results which suggest that radiation interferes with synthesis of DNA. The mean time of replication of the DNA of the hepatocytes was increased from 8 to 13 h following 3,000 r. of X-radiation delivered during the period of synthesis of DNA. The results of both the autoradiographic and cytochemical methods could therefore be interpreted as a radiation-induced reduction of rates of synthesis of DNA. The quantitative autoradiographic examination of DNA synthesis following irradiation recorded here was made to investigate the mechanism of action of irradiation from the characteristics of the dose response curve.
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LOONEY, W., PARDUE, M. & BANGHART, F. Synthesis of Deoxyribonucleic Acid as a Function of the Radiation Dose to the Liver in Partially Hepatectomized Rats. Nature 198, 804–805 (1963). https://doi.org/10.1038/198804a0
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DOI: https://doi.org/10.1038/198804a0
