Abstract
EXPERIMENTAL phenylketonuria has been induced in the rhesus monkey by feeding excess dietary phenyl-alanine1,2. The phenylalanine plasma level was markedly elevated, and the urinary excretion of phenylketones and phenylacetyl glutamine were comparable with that found in children with phenylketonuria. Behavioural and learning tests have demonstrated a severe degree of mental retardation in these experimental animals. This report provides data on the excretion of 5-hydroxyindolyl-acetic acid and indolyl-3-acids in these monkeys and demonstrates that the role of tryptophan is similar in both the experimental disease and in phenylketonuric infants.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on SpringerLink
- Instant access to the full article PDF.
USD 39.95
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Waisman, H. A., Wang, H. L., Palmer, G., and Harlow, H. F., Nature, 188, 1124 (1960).
Waisman, H. A., Wang, H. L., Palmer, G., and Harlow, H. F., Proceedings London Conference on Scientific Study of Mental Retardation, July 1960, 126 (May and Baker, Dagenham, Essex, 1962).
Udenfriend, S. J., Titus, E., and Weissbach, H., J. Biol. Chem., 216, 499 (1955).
Weissbach, H., King, W., Sjoerdsma, A., and Udenfriend, S., J. Biol. Chem., 234, 81 (1959).
Freedland, R. A., Wadzinski, I. M., and Waisman, H. A., Biochem. Biophys. Res. Comm., 6, 227 (1961).
Wang, H. L., Harwalkar, V. H., and Waisman, H. A., Arch. Biochem. Biophys., 97, 181 (1962).
Akedo, H., and Christensen, H. N., J. Biol. Chem., 237, 113 (1962).
McKean, C. M., Schanberg, S. M., and Giarman, N. J., Science, 137, 604 (1962).
Guroff, G., and Udenfriend, S., J. Biol. Chem., 237, 803 (1962).
Armstrong, M. D., and Robinson, K. S., Arch. Biochem. Biophys., 52, 287 (1962).
Toda, K., and Bessman, S. P., Pediatrica Japonica, 3, 41 (1960).
Bessman, S. P., and Toda, K., Metabolism, 9, 377 (1960).
Pare, C. M. B., Sandler, M., and Stacey, R. S., Arch. Diseases in Childhood, 34, 422 (1959).
Pare, C. M. B., Sandler, M., and Stacey, R. S., Lancet, 1099 (1958).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
BOGGS, D., MCLAY, D., KAPPY, M. et al. Excretion of Indolyl Acids in Phenylketonuric Monkeys. Nature 200, 76 (1963). https://doi.org/10.1038/200076a0
Issue date:
DOI: https://doi.org/10.1038/200076a0
