Abstract
Sullivan and Folk1 found that the symmetrical thioether, lanthionine, is converted quantitatively into cysteine by the combined action of cyanogen bromide and sodium cyanide. Although we could confirm the presence of cysteine in the reaction products we were unable to substantiate the quantitative nature of this conversion. The heterocyclic compound 2-iminothiazolidine-4-carboxylic acid, which we detected in the mixture after reaction, could have been formed by further reaction of cysteine on the cyanogen halide and could account for our low cysteine yields.
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References
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VAN RENSBURG, N. Formation of 2-Iminothiazolidine-4-carboxylic Acid in the Cyanobromination of Lanthionine. Nature 200, 672–673 (1963). https://doi.org/10.1038/200672b0
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DOI: https://doi.org/10.1038/200672b0
