Abstract
TRYPAN blue has long been known to possess teratogenic properties1. Several years ago Barber2 reported being able to distinguish mouse fœtuses heterozygous for anophthalmia from those which were homozygous normals by the higher incidence among the former of eye defects in response to trypan blue administered to their dams as a teratogenic agent. All cases of defective eye development were unilateral anophthalmia; the expectation, in the absence of the teratogen, was complete bilateral normality. The anophthalmic mutant has been described in detail elsewhere3,4.
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BECK, S. Frequencies of Teratologies among Homozygous Normal Mice compared with hose Heterozygous for Anophthalmia. Nature 200, 810–811 (1963). https://doi.org/10.1038/200810b0
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DOI: https://doi.org/10.1038/200810b0
