Abstract
THE human placenta is known to be a rich source of choline acetyltransferase (acetyl CoA: choline-o-acetyltransferase E.C. 2.3.1.6)1. Investigations have shown that this enzyme is very similar, in its kinetic behaviour and specificity, to choline acetyltransferase from other sources. In the foregoing work and in the course of purification of the placental enzyme (Morris, D., unpublished) it was of interest to determine its molecular weight, and to compare its sedimentation characteristics with that of rabbit brain enzyme.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 52 print issues and online access
$199.00 per year
only $3.83 per issue
Buy this article
- Purchase on SpringerLink
- Instant access to the full article PDF.
USD 39.95
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Bull, G., Hebb, C. O., and Ratkovic, D., Nature, 190, 1202 (1961).
Martin, R. G., and Ames, B. N., J. Biol. Chem., 236, 1372 (1961).
Yphantis, D. A., and Waugh, D. F., J. Phys. Chem., 60, 630 (1956).
Shantz, E. J., and Lauffer, M. A., Biochem., 1, 658 (1962).
Hebb, C. O., Handbook of Experimental Pharmacology, Supp., edit. by Koelle, G. B., 15 (Springer-Verlag, Berlin, 1963).
Siegel, A., and Bing, R. J., Proc. Soc. Exp. Biol. and Med., 91, 604 (1956).
Thorne, C. J. R., Biochim. Biophys. Acta, 59, 624 (1962).
Schachman, H. K., Ultracentrifuge in Biochemistry (Academic Press, Inc., New York, 1959).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
BULL, G., FEINSTEIN, A. & MORRIS, D. Sedimentation Behaviour and Molecular Weight of Choline Acetyltransferase. Nature 201, 1326 (1964). https://doi.org/10.1038/2011326a0
Issue date:
DOI: https://doi.org/10.1038/2011326a0
This article is cited by
-
Studies on choline acetyltransferase isolated from human brain
Neurochemical Research (1977)
-
Some properties of the cholinacetylase of the human placenta
Bulletin of Experimental Biology and Medicine (1972)


