Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Letter
  • Published:

Deoxyribonuclease II in the Developing Mouse Embryo

Nature volume 201, pages 618–619 (1964)Cite this article

Abstract

THE rapid rate of cell division in early embryogenesis is accompanied by rapid synthesis of DNA1. The function of deoxyribonuclease II (DNase) is essentially catabolic and is probably concerned with the breakdown of DNA from dead cells. DNase would then be expected to be required by the body shortly after embryogenesis and its time of appearance in the star-fish, frog and chicken is essentially similar2. During early embryogenesis of the chick DNase II is difficult to detect but increases rapidly after four daysof incubation2. The onset of DNase activity in the whole mouse embryo and the developing mouse liver has been investigated and been shown to follow a similar ontogenetic pattern as in the other species named here.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on SpringerLink
  • Instant access to the full article PDF.

USD 39.95

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

References

  1. Solomon, J. B., Biochim. Biophys. Acta, 25, 69 (1957).

    Article  CAS  Google Scholar 

  2. Blumenthal, G., J. Embryol. Exp. Morph., 5, 377 (1957).

    CAS  Google Scholar 

  3. Allfrey, V., and Mirsky, A. E., J. Gen. Physiol., 36, 227 (1952).

    Article  CAS  Google Scholar 

  4. Laskowski, M., Arch. Biochem. Biophys., 11, 41 (1946).

    CAS  Google Scholar 

  5. Kirby, K. S., Biochem. J., 66, 495 (1956).

    Article  Google Scholar 

  6. Burton, K., Biochem. J., 62, 315 (1956).

    Article  CAS  Google Scholar 

  7. Sutherland, F. W., Cori, C. F., Haynes, R., and Olsen, N. S., J. Biol. Chem., 180, 825 (1949).

    CAS  PubMed  Google Scholar 

  8. Coleman, J. R., Devel. Biol., 5, 232 (1962).

    Article  CAS  Google Scholar 

  9. de Duve, C., Pressman, B. C., Gianetto, R., Wattiaux, R., and Appelmans, F., Biochem. J., 60, 604 (1955).

    Article  CAS  Google Scholar 

  10. de Duve, C., in Subcellular Particles, edit. by Hayashi, T., 128 (Ronald Press, New York, 1959).

    Google Scholar 

  11. Brody, S., and Theorell, B., Biochim. Biophys. Acta, 25, 579 (1057).

    Article  Google Scholar 

  12. Goutier, R., and Leonard, A., Exp. Cell Res., 28, 335 (1962).

    Article  CAS  Google Scholar 

  13. Weber, R., Experientia, 13, 153 (1957).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Chester Beatty Research Institute, Institute of Cancer Research: Royal Cancer Hospital, Fulham Road, London, S.W.3

    J. B. SOLOMON

Authors
  1. J. B. SOLOMON
    View author publications

    Search author on:PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

SOLOMON, J. Deoxyribonuclease II in the Developing Mouse Embryo. Nature 201, 618–619 (1964). https://doi.org/10.1038/201618a0

Download citation

  • Issue date:

  • DOI: https://doi.org/10.1038/201618a0

This article is cited by

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing