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Species Interaction in the Fibrinogen–Fibrin Conversion

Nature volume 201, pages 707–708 (1964)Cite this article

Abstract

THERE is a considerable body of evidence indicating that a species specificity exists in the interaction of thrombin with fibrinogen. It has been observed that when thrombin of one species reacts with a fibrinogen of another species, the clotting time is longer than it is in the case of thrombin acting on a fibrinogen of its own species1. The rate difference in this interaction could be explained in various ways. One possibility is that the bond split and therefore the peptides released from the same fibrinogen by various thrombins could be different. In order to investigate this, we undertook a study of the peptides released by various thrombins on various fibrinogens. In this communication we report new findings and compare the results of all possible combinations of interaction between human and bovine thrombin with human and bovine fibrinogen.

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Authors and Affiliations

  1. National Institute of Arthritis and Metabolic Diseases, National Institutes of Health, Public Health Service, Education and Welfare, Bethesda, 14, Maryland

    A. J. OSBAHR, J. A. GLADNER, K. LAKI & F. IRREVERRE

Authors
  1. A. J. OSBAHR
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  2. J. A. GLADNER
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  3. K. LAKI
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  4. F. IRREVERRE
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OSBAHR, A., GLADNER, J., LAKI, K. et al. Species Interaction in the Fibrinogen–Fibrin Conversion. Nature 201, 707–708 (1964). https://doi.org/10.1038/201707a0

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