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Dihydromorphine in Peripheral Nervous Tissue

Nature volume 201, page 719 (1964)Cite this article

Abstract

RECENT work has shown that morphine and other narcotic analgesic drugs depress the responses of certain autonomic neuro-effectors to stimulation of their nerves, for example, the cat's nictitating membrane, the rat's and rabbit's sino-auricular node, and the longitudinal muscle of the guinea pig ileum1–5. The inhibition is assumed to be presynaptic because the action of the transmitter, where it can be tested, is not depressed by morphine, and because there is no evidence to show that morphine inhibits impulse transmission in the nerve axons6,7.

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References

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Authors and Affiliations

  1. Department of Physiology, University of Aberdeen,

    H. W. KOSTERLITZ, J. W. THOMPSON & D. I. WALLIS

  2. Department of Pharmacology, Institute of Basic Medical Sciences, Royal College of Surgeons of England, London

    H. W. KOSTERLITZ, J. W. THOMPSON & D. I. WALLIS

Authors
  1. H. W. KOSTERLITZ
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  2. J. W. THOMPSON
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  3. D. I. WALLIS
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KOSTERLITZ, H., THOMPSON, J. & WALLIS, D. Dihydromorphine in Peripheral Nervous Tissue. Nature 201, 719 (1964). https://doi.org/10.1038/201719a0

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