Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Letter
  • Published:

Crystal Structure of N-Acetylglucosamine

Abstract

THE crystal structure of N-acetylglucosamme, C8H15O6N, has been investigated in connexion with the work on lysozyme proceeding in this laboratory1. Salton2 and others have shown that N-acetylglucosamine is a basic constituent of the bacterial cell walls of Micrococcus lysodeikticus, the most commonly used substrate of lysozyme (muramidase), and Wenzel et al.3 have reported that this compound inhibits the action of the enzyme. At a later stage it is hoped to relate the structure to those of lysozyme and its substrates in detail.

This is a preview of subscription content, access via your institution

Access options

Buy this article

USD 39.95

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

References

  1. Blake, C. C. F., Fenn, R. H., North, A. C. T., Phillips, D. C., and Poljak, R. J., Nature, 196, 1173 (1962).

    Article  ADS  CAS  Google Scholar 

  2. Salton, M. R. J., and Ghuysen, J. M., Biochim. Biophys. Acta, 45, 355 (1960).

    Article  CAS  Google Scholar 

  3. Wenzel, M., Link, H. P., and Schutte, E., Z. Physiol. Chem., 327, 13 (1962).

    Article  CAS  Google Scholar 

  4. Arndt, U. W., and Phillips, D. C., Acta Cryst., 14, 807 (1961).

    Article  CAS  Google Scholar 

  5. Jacobson, R. A., Wunderlich, J. A., and Lipscomb, W. N., Acta Cryst., 14, 598 (1961).

    Article  CAS  Google Scholar 

  6. Buerger, M. J., Acta Cryst., 4, 531 (1951).

    Article  CAS  Google Scholar 

  7. Woolfson, M. M., Acta Cryst., 9, 804 (1956).

    Article  CAS  Google Scholar 

  8. Ramachandran, G. N., Ramakrishnan, C., and Sasisekharan, V., in Aspects of Protein Structure, 121 (Academic Press, New York and London, 1963).

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

JOHNSON, L., PHILLIPS, D. Crystal Structure of N-Acetylglucosamine. Nature 202, 588 (1964). https://doi.org/10.1038/202588a0

Download citation

  • Issue date:

  • DOI: https://doi.org/10.1038/202588a0

This article is cited by

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing