Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Letter
  • Published:

Mutagenic Action of Hyponitrous Acid and Glucose Oxime

Nature volume 203, pages 409–410 (1964) Cite this article

Abstract

ONE of us has demonstrated1–5 with his co-workers that hydroxylamine, nitrous acid, hydrogen peroxide, hypo-nitrous acid and oxime can induce viral nuclear poly-hedrosis in healthy silkworms. Among these, the mutagenic action of the first-mentioned three substances has recently been proved by Freese6, Gierer7 and Wyss8. We have now found that acidified hyponitrite and glucosoxime produce a mutation in a bacteriophage.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on SpringerLink
  • Instant access to the full article PDF.

USD 39.95

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

References

  1. Yamafuji, K., and Shirozu, Y., Biochem. Z., 317, 94 (1944).

    Google Scholar 

  2. Yamafuji, K., and Yoshihara, F., Enzymologia, 14, 124 (1950).

    CAS  PubMed  Google Scholar 

  3. Yamafuji, K., and Hirayama, K., Enzymologia, 17, 229 (1955).

    CAS  PubMed  Google Scholar 

  4. Yamafuji, K., and Yoshihara, F., Enzymologia, 22, 89 (1960).

    CAS  PubMed  Google Scholar 

  5. Yamafuji, K., and Omura, H., Enzymologia, 14, 120 (1950).

    CAS  PubMed  Google Scholar 

  6. Freese, E., Bautz-Freese, E., and Bautz, E., J. Mol. Biol., 3, 133 (1961).

    Article  CAS  Google Scholar 

  7. Gierer, A., and Mundry, K. W., Nature, 182, 1457 (1958).

    Article  ADS  CAS  Google Scholar 

  8. Wyss, O., Stone, W. S., and Clark, J. B., J. Bact., 54, 767 (1947).

    CAS  PubMed  Google Scholar 

  9. Jones, L. W., and Scott, A. W., J. Amer. Chem. Soc., 46, 2172 (1924).

    Article  CAS  Google Scholar 

  10. Yamafuji, K., Nature, 167, 770 (1951).

    Article  ADS  CAS  Google Scholar 

  11. Yamafuji, K., Nature, 171, 745 (1953).

    Article  ADS  CAS  Google Scholar 

  12. Yamafuji, K., and Osajima, Y., Nature, 190, 534 (1961).

    Article  ADS  CAS  Google Scholar 

  13. Yamafuji, K., Osajima, Y., and Omura, H., Nature, 185, 162 (1960).

    Article  ADS  CAS  Google Scholar 

  14. Yamafuji, K., and Cho, T., J. Agric. Chem. Soc. Japan, 20, 441 (1944).

    Google Scholar 

  15. Yamafuji, K., Agric. Biochem. Kyushu Univ., 19, 5 (1959).

    Google Scholar 

  16. Yamafuji, K., and Akita, T., Enzymologia, 15, 14 (1951).

    CAS  PubMed  Google Scholar 

  17. Yamafuji, K., Tonokawa, M., and Yoshihara, F., Enzymologia, 23, 111 (1961).

    CAS  PubMed  Google Scholar 

  18. Yamafuji, K., Agric. Biochem. Kyushu Univ., 23, 13 (1963).

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Agricultural Chemistry Institute, Kyushu University, Fukuoka, Japan

    KAZUO YAMAFUJI

  2. Pharmaceutical Institute, Fukuoka University, Fukuoka, Japan

    KENJI WATANABE

Authors
  1. KAZUO YAMAFUJI
    View author publications

    Search author on:PubMed Google Scholar

  2. KENJI WATANABE
    View author publications

    Search author on:PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

YAMAFUJI, K., WATANABE, K. Mutagenic Action of Hyponitrous Acid and Glucose Oxime. Nature 203, 409–410 (1964). https://doi.org/10.1038/203409a0

Download citation

  • Issue date:

  • DOI: https://doi.org/10.1038/203409a0

This article is cited by

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing