Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Letter
  • Published:

Enzymatic Oxidation of Galactose-6-phosphate

Nature volume 204, pages 1304–1305 (1964)Cite this article

Abstract

GALACTOSE-6-phosphate (gal-6-P) has been shown to be produced from galactose-1-phosphate (gal-l-P) in the presence of phosphoglucomutase1, demonstrated in eryth-rocytes of patients with galactosæmia2, and oxidized in the presence of purified glucose-6-phosphate dehydrogenase (G-6-PD) and NADP as indicated by changes in absorbance at 340 mµ (ref. 3). This communication shows that G-6-PD purified from either yeast or human erythrocytes in the presence of NADP converts gal-6-P to 6-phosphogalactonic acid (6-P-gal A).

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on SpringerLink
  • Instant access to the full article PDF.

USD 39.95

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

References

  1. Posternak, T., and Rosselet, J. P., Helv. Chim. Acta., 37, 246 (1954).

    Article  CAS  Google Scholar 

  2. Inouye, T., Tannenbaum, M., and Hsia, D. Y.-Y., Nature, 193, 67 (1962).

    Article  ADS  CAS  Google Scholar 

  3. Kirkman, H. N., J. Biol. Chem., 237, 2364 (1962).

    CAS  PubMed  Google Scholar 

  4. Bartlett, G. R., J. Biol. Chem., 234, 466 (1959).

    CAS  Google Scholar 

  5. Roe, J. H., and Papadopoupos, N. M., J. Biol. Chem., 210, 703 (1954).

    CAS  PubMed  Google Scholar 

  6. Paladini, A. C., and Leloir, L. F., Biochem. J., 51, 426 (1952).

    Article  CAS  Google Scholar 

  7. Lemieux, R. U., and Bauer, H. F., Anal. Chem., 26, 920 (1954).

    Article  CAS  Google Scholar 

  8. Dische, Z., and Borenfreund, E., J. Biol. Chem., 180, 1297 (1949).

    CAS  PubMed  Google Scholar 

  9. Walker, F. A., and Hsia, D. Y.-Y., J. Ped., 59, 872 (1961).

    Article  Google Scholar 

  10. Segal, S., Blair, A., and Topper, Y. J., Science, 136, 150 (1962).

    Article  ADS  CAS  Google Scholar 

  11. Schwarz, V., Wells, A. R., Holzel, A., and Komrower, G. M., Ann. Human Genetics, 25, 179 (1961).

    Article  CAS  Google Scholar 

  12. Hsia, D. Y.-Y., Tannenbaum, M., Schneider, J. A., Huang, S., and Simpson, K., J. Lab. and Clin. Med., 56, 368 (1960).

    CAS  Google Scholar 

  13. Ng, W. G., Bergren, W. R., and Donnell, G. N., Nature, 203, 845 (1964).

    Article  ADS  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Genetic Clinic, Children's Memorial Hospital, Department of Pediatrics, Northwestern University Medical School,

    TOHRU INOUYE, J. ALLAN SCHNEIDER & DAVID YI-YUNG HSIA

  2. Department of Biochemistry, University of Illinois School of Medicine, Chicago

    TOHRU INOUYE, J. ALLAN SCHNEIDER & DAVID YI-YUNG HSIA

Authors
  1. TOHRU INOUYE
    View author publications

    Search author on:PubMed Google Scholar

  2. J. ALLAN SCHNEIDER
    View author publications

    Search author on:PubMed Google Scholar

  3. DAVID YI-YUNG HSIA
    View author publications

    Search author on:PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

INOUYE, T., SCHNEIDER, J. & HSIA, DY. Enzymatic Oxidation of Galactose-6-phosphate. Nature 204, 1304–1305 (1964). https://doi.org/10.1038/2041304a0

Download citation

  • Issue date:

  • DOI: https://doi.org/10.1038/2041304a0

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing