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Serum Enzymes in the Jaundiced Homozygous Gunn Rat

Abstract

IN the course of investigations using jaundiced Gunn1 rats, serum enzyme examinations were performed on these rats and on those of a Wistar strain. Jaundiced homozygous Gunn rats are lacking in hepatic glucuronyl transferase using bilirubin as a substrate. Many workers have established that hepatic cellular damage is associated with elevation of certain serum enzymes, and an investigation was undertaken to compare the serum enzyme levels in jaundiced Gunn rats and those of a Wistar strain to determine whether the jaundice was associated with raised serum enzyme activities.

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HARGREAVES, T., THOM, B. Serum Enzymes in the Jaundiced Homozygous Gunn Rat. Nature 204, 1323 (1964). https://doi.org/10.1038/2041323a0

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