Abstract
PREVIOUS in vitro research1 with the halogenated analogues of orotic acid demonstrated the following basic experimental facts: First, to inhibit the conversion of orotic acid to the uridine nucleotides it was necessary for a drug to be a 5-substituted analogue of orotic acid. For example, it was found that 5-fluoro-orotic acid would inhibit orotic acid conversion, but that 5-fluoro uracil would not. Second, the order of activity of the 5 halogenated orotic acid analogues was fluorine > chlorine > bromine, and the 5-iodo compounds showed little or no activity.
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References
Stone, J. E., and Potter, V. R., Cancer Res., 17, 800 (1957).
Stone, J. E., McManus, N. J., and Levy, M. S., Biochim. Biophys. Acta, 60, 171 (1962).
Bresnick, E., Fed. Proc., 22, 532 (1963).
Kaufman, H. W., Nessburn, A. B., and Maloney, E. D., Arch. Ophthal., 67, 583 (1962).
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STONE, J. Inhibition of Uridine Ribonucleotide Synthesis by 5-Halogenated-2′-deoxyuridine Analogues. Nature 204, 190–191 (1964). https://doi.org/10.1038/204190a0
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DOI: https://doi.org/10.1038/204190a0
