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Esterase Activity of Pepsin

Abstract

IT is known that many proteolytic enzymes—trypsin, chymotrypsin, thrombin, papain and others—hydrolyse peptide, amide and ester bonds. Pepsin, however, is generally believed to hydrolyse the peptide bonds only, without exhibiting the esterase activity1. This conclusion is based on observations which suggest that pepsin does not hydrolyse the ester bonds in several esters of N-substituted amino-acids and peptides, but no special investigation of the esterase activity of pepsin has been published.

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LOKSHINA, L., OREKHOVICH, V. & SKLYANKINA, V. Esterase Activity of Pepsin. Nature 204, 580 (1964). https://doi.org/10.1038/204580a0

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