Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Letter
  • Published:

Serotonin Depletion by Dietary Leucine

Abstract

MAPLE syrup disease (branched-chain ketonuria) is an apparently familial disease associated with mental retardation and biochemically characterized by enhanced urinary excretion of branched-chain amino-acids and their products.

This is a preview of subscription content, access via your institution

Access options

Buy this article

USD 39.95

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

References

  1. Westall, R. G., Dancid, J., and Miller, S., Amer. Med. Assoc. J. Dis. Child., 94, 571 (1957).

    Google Scholar 

  2. Mackenzie, D. Y., and Woolf, L. I., Brit. Med. J., i, 90 (1959).

  3. Tada, K., et al., Tohoku J. Exp. Med., 79, 142 (1963).

    Article  CAS  Google Scholar 

  4. Lane, M. R., J. Pediatrics, 58, 80 (1961).

    Article  CAS  Google Scholar 

  5. Menkes, J. H., Hurst, P. L., and Craig, J. M., Pediatrics, 14, 462 (1964).

    Google Scholar 

  6. Daneis, J., Hutzler, J., and Levitz, M., Pediatrics, 32, 234 (1963).

    Google Scholar 

  7. Tashian, R. E., Metab. Clin. and Exp., 10, 393 (1961).

    CAS  Google Scholar 

  8. Schanberg, S. M. J., J. Pharmacol., 139, 191 (1963).

    CAS  Google Scholar 

  9. Yuwiler, A., Geller, E., and Slater, G. G., Life Sci., 3, 567 (1964).

    Article  CAS  Google Scholar 

  10. Yuwiler, A., and Louttit, R. T., Science, 134, 831 (1961).

    Article  ADS  CAS  Google Scholar 

  11. Strain obtained for Berkeley Pacific and bred by Dr. DaVois of the Veterans Administration Animal Facility.

  12. L-Leucine (methionine-free) obtained from Mann Biochemical Corp.

  13. Bogdanski, D. F., Pletscha, A., Brodie, B. B., and Udenfriend, S., J. Pharmacol. Exp. Therap., 117, 82 (1956).

    CAS  Google Scholar 

  14. Wooley, D. W., and Van der Hoeven, Th., Science, 144, 883 (1964).

    Article  ADS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

YUWILER, A., GELLER, E. Serotonin Depletion by Dietary Leucine. Nature 208, 83–84 (1965). https://doi.org/10.1038/208083a0

Download citation

  • Published:

  • Issue date:

  • DOI: https://doi.org/10.1038/208083a0

This article is cited by

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing