Abstract
RUSSELL1 reported an in vitro synergism between colistin methane sulphonate and sulphonamide drugs using a number of Proteus isolates. He found that the combinations were bactericidal at therapeutic levels, that the ratios of the drugs were not critical, and that the effect was present over a wide range of hydrogen ion concentration. The observations were extended to polymyxin B sulphate and sulphonamides with similar results.
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References
Russell, F. E., J. Clin. Path., 16, 362 (1962).
Mohan, R. R., and Pianotti, R. S., Bacteriol. Proc. (Soc. Amer. Bacteriol.), 99 (1960).
Woods, D. D., Brit. J. Exp. Pathol., 21, 74 (1940).
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GALE, G., ODELL, C. Antagonism of Colistin-sulphonamide Synergism by para-Aminobenzoic Acid. Nature 209, 1357 (1966). https://doi.org/10.1038/2091357a0
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DOI: https://doi.org/10.1038/2091357a0
