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Hepatic Antigen in Sera from Patients with Liver Disease

Abstract

ALMOST one hundred enzyme activities have so far been detected in human sera. There is evidence that most of the serum enzymes are released from tissues, so that tissue constituents can be detected in sera, especially under pathological conditions such as liver disease. In experiments with animals it was shown that liver proteins appeared in the perfusate of the liver1,2, or hepatic antigens in sera with experimental hepatic injury3. This communication reports the existence of hepatic antigen in serum from humans with liver disease.

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HIRAYAMA, C., TODA, T. Hepatic Antigen in Sera from Patients with Liver Disease. Nature 212, 1061–1062 (1966). https://doi.org/10.1038/2121061a0

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