Abstract
WHEN bacterial endotoxin is injected intravenously into mice, an interferon-like vital inhibitor1 and lysosomal enzyme2 can be detected in the plasma. It was suggested that lysosomes are a major target of endotoxin in tissue damage3–5, and it seemed interesting to investigate whether the antiviral activity and the activity of a lysosomal enzyme follow the same pattern of appearance on injection of endotoxin. If this were the case, it would suggest that the viral inhibitor induced by endotoxin can also be released from lysosomes.
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SAUTER, C., GIFFORD, G. Interferon-like Inhibitor and Lysosomal Enzyme induced in Mice injected with Endotoxin. Nature 212, 626 (1966). https://doi.org/10.1038/212626a0
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DOI: https://doi.org/10.1038/212626a0
