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Complex Formation, Isolation and Carcinogenicity of Polycyclic Aromatic Hydrocarbons

Abstract

THE carcinogenic activity of some of the polycyclic aromatic hydrocarbons1,2 present in common materials has focused considerable attention on the properties and isolation of this group of compounds. Many methods for their isolation have been reported which are based, in general, on procedures involving partition3–6, adsorption7–9 or complex formation9,10, used either singly or in combination.

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References

  1. Cook, J., Hieger, I., Kennaway, E., and Mayneord, W., Proc. Roy. Soc., B, 111, 455 (1932).

    Article  ADS  CAS  Google Scholar 

  2. Cook, J., Hewett, C., and Hieger, I., J. Chem. Soc., 395 (1933).

  3. Steidle, W., dissert., Univ. Tübingen (1953).

  4. Grimmer, G., Beitr. Tabakforsch., 7, 291 (1962).

    Google Scholar 

  5. Haemmi, E. O., Howard, J. W., and Joe, F. L., J. Assoc. Offic. Agric. Chemists, 45, 67 (1962).

    Google Scholar 

  6. Golumbic, C., Anal. Chem., 22, 579 (1950).

    Article  CAS  Google Scholar 

  7. Lijinsky, W., Saffiotti, U., and Shubik, P., J. Nat. Cancer Inst., 18, 867 (1957).

    Google Scholar 

  8. Lijinsky, W., Anal. Chem., 32, 684 (1960).

    Article  CAS  Google Scholar 

  9. Van Duuren, B. L., J. Nat. Cancer Inst., 21, 1 (1958).

    CAS  PubMed  Google Scholar 

  10. Tye, R., and Bell, Z., Anal. Chem., 36, 1612 (1964).

    Article  CAS  Google Scholar 

  11. Weil-Malherbe, H., Biochem. J., 40, 351 (1946).

    Article  CAS  Google Scholar 

  12. Brock, N., Druckrey, H., and Hamperl, H., Arch. Exp. Path. Pharmakol., 189, 709 (1938).

    Article  CAS  Google Scholar 

  13. Booth, J., and Boyland, E., Biochim. Biophys. Acta, 12, 75 (1935).

    Article  Google Scholar 

  14. Bruhl, H., Biochem. Z., 212, 291 (1929).

    CAS  Google Scholar 

  15. Keilin, J., Biochem. J., 37, 281 (1943).

    Article  CAS  Google Scholar 

  16. Neish, W. J. P., Rec. Trav. Chim., 67, 361 (1948).

    Article  CAS  Google Scholar 

  17. Mold, J. D., Walker, T. B., and Veasey, L. G., Anal. Chem., 35, 2071 (1963).

    Article  CAS  Google Scholar 

  18. Berg, A., and Lam, J., J. Chromatog., 16, 157 (1964).

    Article  CAS  Google Scholar 

  19. Lam, J., and Berg, A., J. Chromatog., 20, 168 (1965).

    Article  CAS  Google Scholar 

  20. Wanless, G. G., Eby, L. T., and Rehner, J., Anal. Chem., 23, 563 (1951).

    Article  CAS  Google Scholar 

  21. Booth, J., Boyland, E., and Orr, S. F. D., J. Chem. Soc., 598 (1954).

  22. Liquori, A. M., De Lerma, B., Ascoli, F., Botré, C., and Trasciatti, M., J. Mol. Biol., 5, 521 (1962).

    Article  CAS  Google Scholar 

  23. Pullman, B., Claverie, P., and Caillet, J., Science, 147, 1305 (1965).

    Article  ADS  CAS  Google Scholar 

  24. Van Duuren, B. L., Nature, 210, 622 (1966).

    Article  ADS  CAS  Google Scholar 

  25. McKeown, P. J. A., Ubbelohde, A. R., and Woodward, I., Acta Crystallog., 4, 391 (1951).

    Article  CAS  Google Scholar 

  26. Wallwork, S. C., J. Chem. Soc., 494 (1961).

Download references

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ROTHWELL, K., WHITEHEAD, J. Complex Formation, Isolation and Carcinogenicity of Polycyclic Aromatic Hydrocarbons. Nature 213, 797 (1967). https://doi.org/10.1038/213797a0

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