Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Letter
  • Published:

Contribution of Dimers containing Cytosine to Ultra-violet Inactivation of Transforming DNA

Nature volume 213, pages 907–909 (1967)Cite this article

Abstract

BEUKERS1 has shown that dimers containing thymine in DNA irradiated at 2537 Å can be eliminated by further irradiation at 2537 Å in the presence of proflavine, and later work2 has confirmed his hypothesis that the elimination represents splitting of the dimers. We have shown that the biological inactivation of ultra-violet-irradiated transforming DNA from Haemophilus influenzae may similarly be reversed by irradiation in solutions containing proflavine. An investigation of the wavelength dependence of this reactivation in the presence of proflavine, together with information on the reversal of different types of pyrimidine dimers2, has made it possible to evaluate the role of dimers containing cytosine in inactivation.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on SpringerLink
  • Instant access to the full article PDF.

USD 39.95

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

References

  1. Beukers, R., Photochem. Photobiol., 4, 935 (1965).

    Article  CAS  Google Scholar 

  2. Setlow, R., and Carrier, W. L. (preceding communication).

  3. Setlow, J. K., and Setlow, R. B., Proc. U.S. Nat. Acad. Sci., 47, 1619 (1961).

    Article  CAS  ADS  Google Scholar 

  4. Lerman, L. S., J. Cell. Comp. Physiol., 64, suppl. 1, 66 (1964).

    Article  Google Scholar 

  5. Rupert, C. S., and Goodgal, S. H., Nature, 185, 556 (1960).

    Article  CAS  ADS  Google Scholar 

  6. Setlow, R. B., and Setlow, J. K., Proc. U.S. Nat. Acad. Sci., 48, 1250 (1962).

    Article  CAS  ADS  Google Scholar 

  7. Setlow, R. B., and Carrier, W. L., J. Mol. Biol, 17, 237 (1966).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Biology Division, Oak Ridge National Laboratory, Oak Ridge, Tennessee

    JANE K. SETLOW & R. B. SETLOW

Authors
  1. JANE K. SETLOW
    View author publications

    Search author on:PubMed Google Scholar

  2. R. B. SETLOW
    View author publications

    Search author on:PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

SETLOW, J., SETLOW, R. Contribution of Dimers containing Cytosine to Ultra-violet Inactivation of Transforming DNA. Nature 213, 907–909 (1967). https://doi.org/10.1038/213907a0

Download citation

  • Received:

  • Published:

  • Issue date:

  • DOI: https://doi.org/10.1038/213907a0

This article is cited by

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing