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Nissl Substance and Ribosomal Aggregates

Abstract

ONE of the characteristic features of the nerve cells is the large number of basophilic “Nissl granules” in the cytoplasm. Electron microscope studies reveal that the “Nissl substance” is composed of electron dense particles and that these occur either in free form among the membrane structures or are bound to the endoplasmic reticulum1. In the course of the different functional activities of the brain, the distribution and staining properties of these granules change2,3.

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NIEVEL, J., CUMINGS, J. Nissl Substance and Ribosomal Aggregates. Nature 214, 1123–1124 (1967). https://doi.org/10.1038/2141123a0

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