Abstract
FAVISM is a haemolytic anaemia precipitated in some glucose-6-phosphate dehydrogenase (G-6-PD) deficient individuals by the ingestion of fava beans. Although the mechanism of haemolysis in G-6-PD deficient individuals has not been elucidated, it is generally thought that the destruction of reduced glutathione (GSH) is associated with the events which lead to haemolysis1–3. It has been shown that drugs which cause haemolysis in G-6-PD deficient individuals produce a loss of GSH in their erythrocytes in vitro, although it is usually necessary to use a higher concentration of the drug in vitro1 than in vivo.
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KOSOWER, N., KOSOWER, E. Does 3,4-Dihydroxyphenylalanine Play a Part in Favism?. Nature 215, 285–286 (1967). https://doi.org/10.1038/215285a0
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DOI: https://doi.org/10.1038/215285a0
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