Abstract
THERE are two important differences in the way serum proteins separate by zone electrophoresis which employs gels, when compared with paper or moving boundary electrophoresis. First, the sieving effect of the gel alters the mobilities of the proteins and, second, more fractions are resolved. Varying the pore size of the gels excludes from or permits movement of the proteins based on the molecular size and shape relative to the gel pore size.
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HOLLINSHEAD, A., ALFORD, T. Heat-labile Macroglobulin revealed in Adenovirus 12 Tumour Sera by Gel Electrophoresis. Nature 215, 399–400 (1967). https://doi.org/10.1038/215399a0
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DOI: https://doi.org/10.1038/215399a0
