Abstract
AMONG the lymphoproliferative diseases, murine leukaemia has interested many investigators since Gross succeeded in transmitting it with a filtrable agent1. Another lymphoproliferative disease, Aleutian disease of mink2, has received considerable attention because there is a filtrable causative agent3,4. Aleutian disease can be characterized as a transmissible disease of mink and possibly other mustelids5, in which a hypergammaglobulinaemia6 occurs concomitant with a plasma cell proliferation. Unlike murine leukaemia, where the ambiguity of a “filtrable agent” has been resolved by the demonstration of virus particles7, the Aleutian disease agent has remained undetected by electron microscopy (personal communication from R. C. Williams, jun.).
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References
Gross, L., Proc. Soc. Exp. Biol. and Med., 76, 27 (1951).
Helmboldt, C. F., and Jungherr, E. L., Amer. J. Vet. Res., 19, 212 (1958).
Karstad, L., and Pridham, R. J., Canad. J. Comp. Med., 26, 97 (1962).
Trautwein, G. W., Helmboldt, C. F., Amer. J. Vet. Res., 23, 1280 (1962).
Kenyon, A. J., Williams, jun., R. C., and Howard, E. B., Proc. Soc. Exp. Biol. and Med., 102, 919 (1961).
Henson, J. B., Leader, R. W., and Gorham, J. R., Proc. Soc. Exp. Biol. and Med., 123, 510 (1966).
Dirksen, E. R., and Callieu, R., Cancer Res., 27, 568 (1967).
Stent, G. S., Molecular Biology of Viruses, 40 (W. H. Freeman and Company, San Francisco, 1963).
Henson, J. B., Williams, jun., R. C., and Gorham, J. R., J. Immunol., 97, 344 (1966).
Larsen, A. E., and Portor, D. D., Fed. Proc., 26, 482 (1967).
Portor, D., Dixon, F., and Larsen, A., J. Exp. Med., 121, 889 (1965).
Pattison, I. H., and Jones, K. M., Vet. Rec., 80, 2 (1967).
Alper, T., Cramp, W., Haig, D., and Clark, M., Nature, 214, 764 (1967).
Jacob, F., and Monod, J., J. Mol. Biol., 3, 318 (1961).
Monod, J., Changeux, J., and Jacob, F., J. Mol. Biol., 6, 306 (1963).
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BUKO, L., KENYON, A. Aleutian Disease Gammopathy of Mink induced with an Ultra-filtrable Agent. Nature 216, 69–70 (1967). https://doi.org/10.1038/216069a0
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DOI: https://doi.org/10.1038/216069a0
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