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In vivo Interaction of 4-Nitroquinoline-l-oxide and its Derivatives with DNA

Nature volume 216, page 508 (1967)Cite this article

Abstract

4-NITROQUINOLINE-l-OXIDE (4NQO) is a highly carcinogenic compound1. The reductive pathway, which yields 4-hydroxylaminoquinoline-l-oxide (4HAQO), was thought to be essential for its carcinogenic mechanism2,3. There have been reports of the interaction of 4NQO or 4HAQO with DNA in vitro4–6 and in vivo7. This communication deals with the correlation between carcinogenicity and in vivo interaction with DNA by 4NQO derivatives.

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Authors and Affiliations

  1. Biochemistry Division, National Cancer Center Research Institute, Tsukiji, Chuo-ku, Tokyo

    TAIJIRO MATSUSHIMA, IKUKO KOBUNA & TAKASHI SUGIMURA

Authors
  1. TAIJIRO MATSUSHIMA
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  2. IKUKO KOBUNA
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  3. TAKASHI SUGIMURA
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MATSUSHIMA, T., KOBUNA, I. & SUGIMURA, T. In vivo Interaction of 4-Nitroquinoline-l-oxide and its Derivatives with DNA. Nature 216, 508 (1967). https://doi.org/10.1038/216508a0

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