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Single Strand Scissions of DNA caused by a Carcinogen, 4-Hydroxylaminoquinoline I-Oxide

Nature volume 218, page 392 (1968)Cite this article

Abstract

4-HYDROXYLAMINOQUINOLINE I-oxide (4-HAQO) is a reductive product of a carcinogen, 4-nitroquinoline I-oxide (4-NQO), and is thought to be a more procimate carcinogen1–3. Enzyme conversion of 4-NQO to 4-HAQO is known to occur in mammalian cells4. When 4-HAQO or 4-NQO was injected intraperitoneally into rats bearing ascites hepatoma AH-130, DNA isolated from AH-130 cells showed the presence of fluorescent compound which has emission maxima at 470 mµ and excitation maxima at 360 mµ This fluorescent compound seemed to be covalently bound to the DNA molecule5,6. This paper deals with another action of 4-HAQO on DNA, namely that of making single strand scissions of DNA.

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Authors and Affiliations

  1. Biochemistry Division, National Cancer Center Research Institute, Tsukiji, Chuo-ku, Tokyo, Japan

    TAKASHI SUGIMURA, HIDEKI OTAKE & TAIJIRO MATSUSHIMA

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  1. TAKASHI SUGIMURA
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  2. HIDEKI OTAKE
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  3. TAIJIRO MATSUSHIMA
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SUGIMURA, T., OTAKE, H. & MATSUSHIMA, T. Single Strand Scissions of DNA caused by a Carcinogen, 4-Hydroxylaminoquinoline I-Oxide. Nature 218, 392 (1968). https://doi.org/10.1038/218392a0

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