Abstract
ACTINOMYCIN D, a potent inhibitor of nucleic acid syntheses1, has been used in many developing systems to determine immediately gene-dependent events2. Gabriel3 concluded that actinomycin inhibits cephalic regeneration of the planarian Dugesia gonocephala “mainly during the first 24 hours following amputation”. Previous investigations4, however, have suggested that this early period is one of non-specific proliferation and that the definitive gene-dependent events occur later in development.
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References
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COWARD, S. Effects of Actinomycin D on Regeneration give Evidence of Sequential Gene Activation. Nature 219, 1257–1258 (1968). https://doi.org/10.1038/2191257a0
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DOI: https://doi.org/10.1038/2191257a0
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