Abstract
WHILE investigating some fundamental interactions of amino-acids with nucleotides, we became interested in the possibility of attaching adenosine 5′-monophosphate (AMP) to an insoluble support. If AMP could be bound to a polymer frame by means of the phosphate function, the result would be a reactive site (template) which bears some resemblance to the amino-acid acceptor terminus of a transfer (soluble) ribonucleic acid (tRNA)1. The similarity is represented schematically in Fig. 1.
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References
Mahler, H. R., and Cordes, E. H., Biological Chemistry, 796 (Harper and Row, New York, 1966).
Merrifield, R. B., J. Amer. Chem. Soc., 85, 2149 (1963).
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HARPOLD, M., CALVIN, M. AMP on an Insoluble Solid Support. Nature 219, 486 (1968). https://doi.org/10.1038/219486a0
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DOI: https://doi.org/10.1038/219486a0
