Abstract
Proteases from the sea anemone have the same zymogen activation and active site chemistry as the proteases of the mammalian pancreas. One of them has kinetic properties remarkably similar to chymotrypsin. The findings suggest a common ancestry for the digestive process of mammals and coelenterates.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 52 print issues and online access
$199.00 per year
only $3.83 per issue
Buy this article
- Purchase on SpringerLink
- Instant access to the full article PDF.
USD 39.95
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Hartley, B. S., Brown, J. R., Kauffman, D. L., and Smillie, L. B., Nature, 207, 1157 (1965).
Walsh, K. A., and Neurath, H., Proc. US Nat. Acad. Sci., 52, 884 (1964).
Ingram, V. M., Nature, 189, 704 (1961).
Dixon, G. H., Kauffman, D. L., and Neurath, H., J. Biol. Chem., 233, 1373 (1958).
Oosterbaan, R. A., Kunst, P., van Rotterdam, J., and Cohen, J. A., Biochim. Biophys. Acta, 27, 549, 556 (1958).
Sanger, F., Proc. Chem. Soc., 76 (1963).
Schoellman, G., and Shaw, E., Biochemistry, 2, 252 (1963).
Shaw, E., Mares-Guia, M., and Cohen, W., Biochemistry, 4, 2219 (1965).
Neurath, H., Adv. Prot. Chem., 12, 320 (1957).
Desnuelle, P., in The Enzymes, 4 (edit. by Boyer, P. D., Lardy, H., arid Myrback, M.), 119 (Academic Press, New York, 1960).
Mathews, B. W., Sigler, P. B., Henderson, R., and Blow, D. M., Nature, 214, 652 (1967).
Thompson, D. W., The Works of Aristotle, 4, Historia Animalium, book IV, pt. 6, para. 531b (Clarendon Press, Oxford, 1962).
Bodansky, M., Amer. J. Physiol., 63, 547 (1923).
Davis, B. J., Ann. NY Acad. Sci., 21, 404 (1964).
Smithies, O., Connell, G. E., and Dixon, G. H., Amer. J. Genet., 14, 14 (1962).
Naughton, M. A., Sanger, F., Hartley, B. S., and Shaw, D. C., Biochem. J., 77, 149 (1960).
Mares-Guia, M., and Shaw, E., J. Biol. Chem., 240, 1579 (1965).
Whitaker, D. R., and Roy, C., Canad. J. Biochem., 45, 911 (1967).
Dixon, G. H., Essays in Biochemistry (edit. by Campbell, P. N., and Greville, G. D.), 2, 147 (Biochemical Society, London, 1966).
Neurath, H., Walsh, K. A., and Winter, W. P., Science, 158, 1638 (1967).
Bromer, W. W., Sinn, L. G., and Behrens, O. K., J. Amer. Chem. Soc., 79, 2798 (1957).
Enenkel, A. G., and Smillie, L. B., Biochemistry, 2, 1445 (1963).
Smillie, L. B., and Whitaker, D. R., J. Amer. Chem. Soc., 89, 3350 (1967).
Smith, E. L., Markland, F. S., Kaspar, C. B., DeLange, R. J., Landon, M., and Evans, W. H., J. Biol. Chem., 241, 5974 (1966).
Morton, R. K., in Methods in Enzymology, 1 (edit. by Colowick, S. P., and Kaplan, N. O.), 25 (Academic Press, New York, 1955).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
GIBSON, D., DIXON, G. Chymotrypsin-like Proteases from the Sea Anemone, Metridium senile. Nature 222, 753–756 (1969). https://doi.org/10.1038/222753a0
Received:
Issue date:
DOI: https://doi.org/10.1038/222753a0
This article is cited by
-
The digestive system of the stony coral Stylophora pistillata
Cell and Tissue Research (2017)
-
Digestive flexibility in response to environmental salinity and temperature in the non-symbiotic sea anemone Bunodosoma zamponii
Hydrobiologia (2015)
-
Isolierung und Strukturaufkl�rung eines h�molytisch aktiven Peptids aus der Seeanemone Metridium senile
Naturwissenschaften (1987)
-
Feeding factors for the sea anemone Anthopleura midorii
Marine Biology (1973)
-
Die molekulare Evolution proteolytischer Enzyme
Die Naturwissenschaften (1972)
