Abstract
ISOTOPIC methods can be used in two ways for studying the turnover rates of tissue proteins in the living animal: either the rate of catabolism may be measured from the rate of breakdown of labelled protein, or the rate of synthesis from the rate of uptake of label into unlabelled protein. In the steady state the two rates will, of course, be equal. Calculation of the catabolic rate from the decay curve of a labelled protein is valid only if there is no recycling of the label; a condition which, with certain exceptions, is not met in experiments with labelled amino-acids.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on SpringerLink
- Instant access to the full article PDF.
USD 39.95
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Henriques, O. B., Henriques, S. B., and Neuberger, A., Biochem. J., 60, 409 (1955).
Waterlow, J. C., and Stephen, J. M. L., Clin. Sci., 33, 489 (1967).
Waterlow, J. C., and Stephen, J. M. L., Clin. Sci., 35, 287 (1968).
Thin Layer Chromatography (edit. by Stahl, E.), 424 (Springer-Verlag, Berlin, 1965).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
GARLICK, P. Turnover Rate of Muscle Protein measured by Constant Intravenous Infusion of 14C-Glycine. Nature 223, 61–62 (1969). https://doi.org/10.1038/223061a0
Received:
Issue date:
DOI: https://doi.org/10.1038/223061a0
