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Gonadotrophin Inhibitory Properties of Pineal Extracts

Nature volume 228, page 1202 (1970)Cite this article

Abstract

EXTRACTS of urine and pineal are capable of inhibiting the activity of human chorionic gonadotrophin (HCG) in the mouse uterus assay1,2. The failure to detect an inhibitor in urine from patients with sexual precocity due to pinealoma suggested that the pineal was the source of the urinary gonadotrophin inhibitor1. On the other hand, the presence of a gonadotrophin inhibitor in the pineal or in urine has been doubted3,4 or the effects of the latter have been ascribed to the toxicity of the extracts used5. The gonadotrophin inhibitory properties of pineal extracts clearly warrant further investigation and I report here the effects of a pineal extract on gonadotrophin responses in the mouse uterus assay.

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Authors and Affiliations

  1. Sub-department of Endocrine Pathology, Liverpool Clinic, Myrtle St., Liverpool, 7

    L. J. HIPKIN

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  1. L. J. HIPKIN
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HIPKIN, L. Gonadotrophin Inhibitory Properties of Pineal Extracts. Nature 228, 1202 (1970). https://doi.org/10.1038/2281202a0

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  • DOI: https://doi.org/10.1038/2281202a0

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